Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD	1.05e-03	2.02e-02	5.92e-04	1.01e-05
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	4.93e-01	2.21e-01	6.60e-08	8.59e-02
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD Exclusive	5.68e-03	6.15e-02	2.14e-03	1.03e-05
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	4.05e-01	2.52e-01	2.35e-08	7.53e-02
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	3.96e-02	5.94e-02	3.96e-02	7.92e-02
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.51e-03	2.12e-02	1.63e-08	1.95e-02



Evaluating how well Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD	0.84	3.02	3.24	2.22	5.08
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	0.56	2.19	2.34	2.80	2.39
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD Exclusive	0.83	2.34	2.26	2.09	4.89
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	0.56	1.89	2.11	2.42	2.62
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	0.97	1.63	1.95	1.86	1.77
Ismael_14_AD Exclusive	Overlap	1.00	5.17	1.50	2.34	1.59
Overlap	Exclusives	0.55	0.78	1.30	1.05	2.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD	0.01	7.91	9.54	6.06	11.18
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	0.01	4.85	6.32	5.79	4.34
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Ismael_14_AD Exclusive	0.01	4.32	8.39	5.64	10.96
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	0.01	1.70	3.40	2.66	3.89
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	0.00	6.25	0.79	5.21	0.83
Ismael_14_AD Exclusive	Overlap	0.25	682.32	471.33	632.58	25.00
Overlap	Exclusives	0.02	9.02	21.58	12.02	12.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	149	146	CHURC1-FNTB;TMEM191C;AC187653.1
Ismael_14_AD Exclusive	13	13	
Overlap	1	1