Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31	8.38e-01	9.91e-01	6.94e-01	1.06e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	5.22e-01	5.85e-02	5.53e-02	3.96e-02
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31 Exclusive	9.89e-01	9.95e-01	9.82e-01	3.13e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	6.07e-01	1.64e-01	7.54e-02	6.09e-02
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	4.95e-01	5.71e-01	5.37e-01	2.52e-02
tier1_31 Exclusive	Overlap	9.14e-09	1.83e-09	2.74e-08	6.04e-07
Overlap	Exclusives	4.89e-03	2.58e-03	2.23e-10	3.93e-04



Evaluating how well Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31	0.62	0.61	0.36	0.50	2.21
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	0.54	1.13	1.75	1.61	1.68
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31 Exclusive	0.60	0.29	0.16	0.14	1.79
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	0.53	1.03	1.10	1.25	1.60
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	0.82	1.16	0.91	1.11	2.25
tier1_31 Exclusive	Overlap	1.00	2.97	2.30	2.69	3.36
Overlap	Exclusives	0.59	4.42	3.85	3.05	4.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31	0.00	0.13	-0.16	0.08	0.98
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS	0.01	3.18	2.62	2.36	2.59
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	tier1_31 Exclusive	0.00	-0.09	-0.10	0.02	-0.01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	0.01	0.46	0.05	0.38	0.92
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	Overlap	0.00	-0.17	-0.39	-0.23	0.37
tier1_31 Exclusive	Overlap	0.05	94.22	133.42	51.75	84.81
Overlap	Exclusives	0.03	27.91	24.24	16.56	24.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_no_CCS Exclusive	146	143	AC187653.1;CHURC1-FNTB;TMEM191C
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4