Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31	2.16e-01	4.12e-01	6.38e-01	6.34e-02
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS	2.78e-01	8.23e-01	8.89e-01	8.70e-01
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31 Exclusive	2.29e-01	3.35e-01	7.10e-01	1.87e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	2.22e-01	7.28e-01	9.90e-01	9.00e-01
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	Overlap	1.70e-01	5.77e-03	6.63e-02	1.02e-02
tier1_31 Exclusive	Overlap	4.36e-07	4.36e-07	1.74e-06	8.71e-06
Overlap	Exclusives	9.55e-06	1.69e-05	1.75e-10	6.80e-06



Evaluating how well Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31	0.58	-0.46	-0.18	-0.05	1.43
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS	0.53	-0.70	-0.98	-0.36	0.79
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31 Exclusive	0.56	-0.93	-0.96	-0.35	0.99
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	0.50	-1.27	-1.35	-0.91	0.12
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	Overlap	0.81	1.10	1.99	1.27	2.10
tier1_31 Exclusive	Overlap	1.00	2.69	2.60	2.57	2.90
Overlap	Exclusives	0.67	4.39	4.81	2.72	5.68

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31	0.00	-0.87	-0.47	-0.43	0.09
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS	0.01	4.23	3.27	4.48	4.32
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	tier1_31 Exclusive	0.00	-0.91	-0.57	-0.51	-0.15
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	0.00	-0.98	-1.20	-0.82	-0.25
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	Overlap	0.00	-0.13	0.17	0.16	-0.05
tier1_31 Exclusive	Overlap	0.04	125.98	151.81	84.68	49.89
Overlap	Exclusives	0.03	38.46	47.79	23.74	54.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5_no_CCS Exclusive	61	59	CHURC1-FNTB;TMEM191C
tier1_31 Exclusive	28	27	MS4A
Overlap	3	3