Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
female Exclusive	GWAS	7.51e-01	5.60e-01	7.51e-01	4.07e-02
GWAS Exclusive	female	1.28e-01	9.70e-01	5.64e-01	3.00e-01
female Exclusive	GWAS Exclusive	7.84e-01	5.77e-01	6.90e-01	5.05e-02
GWAS Exclusive	female Exclusive	1.31e-01	9.86e-01	8.84e-01	4.41e-01
female Exclusive	Overlap	7.72e-01	1.98e-02	8.51e-01	3.17e-01
GWAS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.41e-03	4.39e-03	8.54e-28	2.16e-03



Evaluating how well female genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
female Exclusive	GWAS	0.61	0.32	-0.70	-0.10	1.97
GWAS Exclusive	female	0.55	-0.52	0.13	0.18	1.48
female Exclusive	GWAS Exclusive	0.60	0.59	-0.63	0.01	1.78
GWAS Exclusive	female Exclusive	0.54	-0.51	0.23	-0.20	1.10
female Exclusive	Overlap	0.83	-0.08	-231079638467934.00	-0.28	1.13
GWAS Exclusive	Overlap	1.00	1.28	inf	1.64	1.79
Overlap	Exclusives	0.63	inf	3.23	1.85	4.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
female Exclusive	GWAS	0.00	-0.20	-0.96	-0.44	0.44
GWAS Exclusive	female	0.00	0.24	0.78	0.18	0.97
female Exclusive	GWAS Exclusive	0.00	0.05	-0.98	-0.34	0.24
GWAS Exclusive	female Exclusive	0.00	-0.53	0.09	-0.21	-0.01
female Exclusive	Overlap	0.00	-0.47	-2364313755408497.00	-0.39	-0.13
GWAS Exclusive	Overlap	0.02	13.99	inf	59.68	17.10
Overlap	Exclusives	0.01	6837825627499142.00	12.91	7.50	13.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
female Exclusive	68	68	
GWAS Exclusive	24	24	
Overlap	1	1