Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_PD Exclusive	Botas	7.19e-01	4.34e-01	5.65e-05	6.12e-02
Botas Exclusive	Cauchy_PD	3.99e-16	3.92e-01	1.56e-11	1.72e-07
Cauchy_PD Exclusive	Botas Exclusive	4.94e-01	3.57e-01	1.98e-04	6.43e-02
Botas Exclusive	Cauchy_PD Exclusive	1.47e-16	3.57e-01	3.07e-11	2.08e-07
Cauchy_PD Exclusive	Overlap	8.71e-01	6.14e-01	1.98e-01	4.36e-01
Botas Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	1.29e-12	1.15e-07	3.95e-37	1.74e-21



Evaluating how well Cauchy_PD genes are linked to Botas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_PD Exclusive	Botas	0.56	0.19	-0.29	0.35	1.39
Botas Exclusive	Cauchy_PD	0.60	-1.73	-0.92	-1.18	4.62
Cauchy_PD Exclusive	Botas Exclusive	0.55	-0.09	-0.65	0.16	1.58
Botas Exclusive	Cauchy_PD Exclusive	0.60	-1.99	-1.15	-1.53	4.61
Cauchy_PD Exclusive	Overlap	0.82	0.18	0.80	0.47	1.05
Botas Exclusive	Overlap	1.00	1.42	1.69	1.59	1.76
Overlap	Exclusives	0.72	2.03	6.91	2.71	10.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_PD Exclusive	Botas	0.00	-0.19	-0.83	-0.18	-0.15
Botas Exclusive	Cauchy_PD	0.01	-1.04	-0.20	-0.38	3.26
Cauchy_PD Exclusive	Botas Exclusive	0.00	-0.37	-1.06	-0.29	-0.18
Botas Exclusive	Cauchy_PD Exclusive	0.01	-1.42	-0.57	-0.76	2.50
Cauchy_PD Exclusive	Overlap	0.00	-0.29	0.30	-0.22	-0.07
Botas Exclusive	Overlap	0.01	27.36	4.88	21.14	8.17
Overlap	Exclusives	0.04	2.35	22.95	8.17	29.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_PD Exclusive	160	159	
Botas Exclusive	48	48	
Overlap	1	1