Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LD Organization Exclusive	Sigma_AD_Male	9.98e-02	8.04e-01	5.21e-01	9.71e-01
Sigma_AD_Male Exclusive	LD Organization	3.11e-01	3.75e-01	2.86e-01	8.39e-01
LD Organization Exclusive	Sigma_AD_Male Exclusive	7.96e-02	6.90e-01	3.02e-01	8.53e-01
Sigma_AD_Male Exclusive	LD Organization Exclusive	3.47e-01	4.38e-01	4.52e-01	9.32e-01
LD Organization Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Sigma_AD_Male Exclusive	Overlap	7.92e-01	7.92e-01	9.90e-01	5.35e-01
Overlap	Exclusives	2.42e-03	2.48e-03	7.99e-04	1.55e-03



Evaluating how well LD Organization genes are linked to Sigma_AD_Male genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LD Organization Exclusive	Sigma_AD_Male	0.50	0.14	-0.53	-0.35	0.00
Sigma_AD_Male Exclusive	LD Organization	0.50	-0.82	-1.07	-0.67	-0.12
LD Organization Exclusive	Sigma_AD_Male Exclusive	0.49	-0.15	-0.87	-0.74	-0.29
Sigma_AD_Male Exclusive	LD Organization Exclusive	0.50	-0.86	-1.19	-0.68	0.12
LD Organization Exclusive	Overlap	1.00	2.58	2.21	1.93	1.78
Sigma_AD_Male Exclusive	Overlap	0.26	-0.07	-0.23	-0.28	-0.85
Overlap	Exclusives	0.58	2.04	2.36	1.66	3.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LD Organization Exclusive	Sigma_AD_Male	0.01	1.97	1.03	1.26	1.35
Sigma_AD_Male Exclusive	LD Organization	0.00	-0.09	0.24	-0.11	-0.09
LD Organization Exclusive	Sigma_AD_Male Exclusive	0.00	-0.25	-0.53	-0.59	-0.28
Sigma_AD_Male Exclusive	LD Organization Exclusive	0.00	0.10	0.34	0.06	0.17
LD Organization Exclusive	Overlap	0.06	174.72	379.38	125.27	349.28
Sigma_AD_Male Exclusive	Overlap	0.00	-0.19	-0.21	-0.40	-0.24
Overlap	Exclusives	0.02	10.50	7.70	7.30	16.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LD Organization Exclusive	31	31	
Sigma_AD_Male Exclusive	81	81	
Overlap	1	1