Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	Ismael_14_AD	7.42e-01	8.67e-01	8.22e-01	3.05e-02
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	1.21e-02	9.83e-01	1.24e-05	9.72e-01



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	Ismael_14_AD	0.70	0.51	0.11	0.51	2.84
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	0.50	-0.69	0.07	0.27	0.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	Ismael_14_AD	0.00	-0.04	-0.46	-0.10	1.36
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	0.01	-0.14	0.15	0.30	0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	146	144	CHURC1-FNTB;AC139530.2
Ismael_14_AD	14	14