Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31	1.29e-01	3.03e-01	2.85e-01	5.65e-01
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	3.91e-01	5.67e-01	4.94e-01	8.95e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31 Exclusive	1.57e-01	1.75e-01	1.72e-01	8.23e-01
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	3.56e-01	5.70e-01	6.52e-01	6.97e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	Overlap	9.32e-01	6.98e-01	8.43e-01	2.20e-01
ad_tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	3.84e-07
Overlap	Exclusives	1.17e-02	6.31e-03	3.97e-13	2.04e-03



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31	0.56	-1.15	-1.42	-0.68	0.91
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	0.50	0.28	0.04	0.21	0.01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31 Exclusive	0.53	-1.11	-1.15	-0.72	0.47
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	0.49	-0.15	-0.54	-0.12	-0.42
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	Overlap	0.72	0.35	-0.04	0.55	1.67
ad_tier1_31 Exclusive	Overlap	1.00	2.95	3.04	2.68	3.31
Overlap	Exclusives	0.57	3.95	3.83	3.66	3.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31	0.00	-0.71	-1.21	-0.64	-0.03
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3	0.01	2.86	2.10	1.53	1.92
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	ad_tier1_31 Exclusive	0.00	-0.84	-0.85	-0.40	-0.22
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	0.01	-0.44	-1.05	-0.58	-0.85
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	Overlap	0.00	-0.52	-1.17	-0.38	0.61
ad_tier1_31 Exclusive	Overlap	0.05	133.14	169.51	139.82	110.48
Overlap	Exclusives	0.03	27.20	27.63	16.63	18.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_ACyounger86_HColder74_z_3 Exclusive	142	140	AC139530.2;CHURC1-FNTB
ad_tier1_31 Exclusive	27	26	MS4A
Overlap	4	4