Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
B Exclusive	C	5.34e-03	4.24e-03	3.49e-12	9.01e-09
C Exclusive	B	4.54e-04	9.65e-05	2.56e-07	2.88e-11
B Exclusive	C Exclusive	9.20e-02	6.23e-02	4.94e-07	1.19e-04
C Exclusive	B Exclusive	5.64e-03	1.72e-03	8.93e-06	1.78e-10
B Exclusive	Overlap	7.07e-02	3.56e-02	4.51e-07	1.35e-06
C Exclusive	Overlap	6.00e-02	1.96e-02	2.50e-03	1.45e-04
Overlap	Exclusives	1.44e-04	3.07e-04	8.51e-15	9.27e-12



Evaluating how well B genes are linked to C genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B Exclusive	C	0.68	4.59	4.95	4.29	6.63
C Exclusive	B	0.71	3.55	5.64	4.04	7.56
B Exclusive	C Exclusive	0.64	3.82	4.00	3.35	4.63
C Exclusive	B Exclusive	0.73	3.24	4.15	2.96	5.99
B Exclusive	Overlap	0.73	2.83	3.90	3.94	5.30
C Exclusive	Overlap	0.69	2.45	2.84	2.80	4.74
Overlap	Exclusives	0.68	4.42	4.36	4.25	7.76

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B Exclusive	C	0.01	8.06	7.43	3.73	6.01
C Exclusive	B	0.01	3.51	5.53	5.10	6.19
B Exclusive	C Exclusive	0.01	4.00	2.55	3.55	3.30
C Exclusive	B Exclusive	0.01	3.36	4.99	4.20	7.52
B Exclusive	Overlap	0.01	7.86	13.40	17.74	3.78
C Exclusive	Overlap	0.00	1.81	1.68	0.61	4.04
Overlap	Exclusives	0.02	6.03	6.79	7.03	11.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
B Exclusive	70	68	CHD2;UGT2A1
C Exclusive	83	82	6-Mar
Overlap	54	50	AC003002.1;AC100868.1;USP9Y;NLGN4Y