Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
A Exclusive	C	5.53e-02	2.42e-01	5.05e-07	2.18e-05
C Exclusive	A	3.66e-01	1.42e-01	3.38e-03	1.16e-03
A Exclusive	C Exclusive	2.02e-01	5.80e-01	5.01e-07	1.29e-04
C Exclusive	A Exclusive	7.86e-01	5.23e-01	9.38e-02	5.45e-02
A Exclusive	Overlap	3.06e-01	7.33e-01	1.13e-01	6.94e-02
C Exclusive	Overlap	4.03e-01	3.92e-01	8.72e-02	2.27e-02
Overlap	Exclusives	1.03e-01	1.13e-02	4.50e-08	1.45e-09



Evaluating how well A genes are linked to C genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	C	0.62	2.01	2.01	1.82	4.81
C Exclusive	A	0.68	1.85	2.11	2.25	3.28
A Exclusive	C Exclusive	0.62	1.20	1.46	1.58	4.47
C Exclusive	A Exclusive	0.67	0.80	1.47	1.49	2.48
A Exclusive	Overlap	0.66	1.60	1.32	1.90	2.32
C Exclusive	Overlap	0.68	1.75	1.75	1.55	2.61
Overlap	Exclusives	0.63	1.62	2.41	2.07	4.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	C	0.01	1.27	2.23	2.40	2.83
C Exclusive	A	0.00	0.31	3.52	4.33	0.71
A Exclusive	C Exclusive	0.01	1.15	1.68	2.59	1.94
C Exclusive	A Exclusive	0.00	1.82	2.41	5.18	4.46
A Exclusive	Overlap	0.00	0.59	0.59	1.24	0.44
C Exclusive	Overlap	0.00	0.24	0.49	0.38	0.30
Overlap	Exclusives	0.01	1.51	2.02	1.96	3.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
A Exclusive	20	19	UGT2A1
C Exclusive	121	117	AC100868.1;NLGN4Y;6-Mar;USP9Y
Overlap	16	15	AC003002.1