Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eqtl train Exclusive	lambert	1.18e-05	1.54e-05	1.04e-05	1.23e-08
lambert Exclusive	eqtl train	2.65e-02	7.24e-02	8.56e-04	6.28e-03
eqtl train Exclusive	lambert Exclusive	2.01e-05	1.64e-05	1.75e-05	8.78e-08
lambert Exclusive	eqtl train Exclusive	8.81e-02	7.30e-02	1.19e-03	3.08e-02
eqtl train Exclusive	Overlap	7.13e-01	3.74e-01	6.58e-01	1.00e-01
lambert Exclusive	Overlap	1.74e-06	1.00e-01	1.74e-06	1.52e-05
Overlap	Exclusives	7.84e-04	2.61e-05	6.67e-24	1.32e-07



Evaluating how well eqtl train genes are linked to lambert genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl train Exclusive	lambert	0.69	4.38	5.66	3.85	7.84
lambert Exclusive	eqtl train	0.57	2.94	2.12	2.20	2.87
eqtl train Exclusive	lambert Exclusive	0.69	3.82	4.68	3.67	5.94
lambert Exclusive	eqtl train Exclusive	0.56	2.45	1.68	1.93	2.23
eqtl train Exclusive	Overlap	0.84	1.32	1.50	1.23	2.06
lambert Exclusive	Overlap	0.99	3.27	2.16	2.69	3.09
Overlap	Exclusives	0.61	3.03	4.27	2.47	6.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl train Exclusive	lambert	0.02	7.96	27.62	18.48	30.86
lambert Exclusive	eqtl train	0.02	9.90	14.56	5.58	6.69
eqtl train Exclusive	lambert Exclusive	0.02	12.83	21.26	12.92	24.32
lambert Exclusive	eqtl train Exclusive	0.02	11.52	12.57	6.47	5.38
eqtl train Exclusive	Overlap	0.01	23.26	74.44	37.60	28.41
lambert Exclusive	Overlap	0.01	20.11	16.98	27.98	85.75
Overlap	Exclusives	0.03	11.55	15.62	8.00	16.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eqtl train Exclusive	151	150	CLEC20A
lambert Exclusive	99	93	TNSF13;IGH;TNSF12;MS4A;AC074212.3;APT8B4
Overlap	3	3