Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EA Exclusive	eQTL SPLICe	1.73e-02	2.05e-02	1.17e-01	1.60e-04
eQTL SPLICe Exclusive	EA	4.76e-01	6.10e-01	1.48e-01	9.03e-01
EA Exclusive	eQTL SPLICe Exclusive	4.97e-02	3.57e-02	1.88e-01	2.81e-04
eQTL SPLICe Exclusive	EA Exclusive	5.37e-01	5.90e-01	1.09e-01	9.25e-01
EA Exclusive	Overlap	4.67e-01	5.05e-01	4.76e-01	1.85e-01
eQTL SPLICe Exclusive	Overlap	8.14e-01	9.46e-01	6.00e-01	3.28e-01
Overlap	Exclusives	2.28e-01	4.74e-01	2.27e-05	6.54e-02



Evaluating how well EA genes are linked to eQTL SPLICe genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	eQTL SPLICe	0.58	2.79	3.36	2.72	4.88
eQTL SPLICe Exclusive	EA	0.53	1.33	1.34	1.45	0.69
EA Exclusive	eQTL SPLICe Exclusive	0.58	2.57	2.51	2.80	4.84
eQTL SPLICe Exclusive	EA Exclusive	0.51	0.92	1.18	1.23	0.28
EA Exclusive	Overlap	0.68	1.05	1.75	1.35	2.11
eQTL SPLICe Exclusive	Overlap	0.61	0.20	0.52	0.30	1.17
Overlap	Exclusives	0.54	1.35	0.91	0.87	2.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EA Exclusive	eQTL SPLICe	0.02	2.25	2.20	1.86	2.87
eQTL SPLICe Exclusive	EA	0.01	9.79	6.28	9.61	1.52
EA Exclusive	eQTL SPLICe Exclusive	0.02	1.44	2.05	1.77	3.04
eQTL SPLICe Exclusive	EA Exclusive	0.00	5.95	2.10	3.73	2.99
EA Exclusive	Overlap	0.00	1.36	1.19	1.11	1.17
eQTL SPLICe Exclusive	Overlap	0.00	9.04	25.12	8.26	12.51
Overlap	Exclusives	0.02	1.93	1.69	1.29	2.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EA Exclusive	65	64	CHURC1-FNTB
eQTL SPLICe Exclusive	261	261	
Overlap	11	11