Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
eqtl whole within brain Exclusive	gwas	7.24e-01	2.86e-01	1.51e-01	3.96e-03
gwas Exclusive	eqtl whole within brain	3.65e-02	8.25e-01	6.28e-02	3.49e-01
eqtl whole within brain Exclusive	gwas Exclusive	4.84e-01	9.22e-02	7.09e-02	1.46e-03
gwas Exclusive	eqtl whole within brain Exclusive	4.73e-02	7.14e-01	2.76e-02	2.94e-01
eqtl whole within brain Exclusive	Overlap	4.55e-01	4.16e-01	7.33e-01	7.72e-01
gwas Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.49e-02	1.44e-02	7.99e-03	5.65e-04



Evaluating how well eqtl whole within brain genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl whole within brain Exclusive	gwas	0.69	0.40	1.25	1.04	3.22
gwas Exclusive	eqtl whole within brain	0.52	-0.33	-0.41	-0.10	0.81
eqtl whole within brain Exclusive	gwas Exclusive	0.70	0.72	2.02	1.31	3.18
gwas Exclusive	eqtl whole within brain Exclusive	0.52	-0.57	-0.76	-0.07	0.80
eqtl whole within brain Exclusive	Overlap	0.38	-1.04	-0.81	-0.64	-0.44
gwas Exclusive	Overlap	1.00	2.14	1.76	1.76	1.50
Overlap	Exclusives	0.59	1.70	2.89	1.56	3.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
eqtl whole within brain Exclusive	gwas	0.00	-0.37	0.30	0.15	1.58
gwas Exclusive	eqtl whole within brain	0.01	0.84	0.69	0.41	1.39
eqtl whole within brain Exclusive	gwas Exclusive	0.00	-0.30	0.71	0.43	1.84
gwas Exclusive	eqtl whole within brain Exclusive	0.01	0.12	-0.14	0.65	0.89
eqtl whole within brain Exclusive	Overlap	0.00	-0.72	-0.80	-0.44	-0.36
gwas Exclusive	Overlap	0.01	12.63	17.98	7.24	18.56
Overlap	Exclusives	0.01	2.83	4.43	3.38	6.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
eqtl whole within brain Exclusive	125	124	IQANK1
gwas Exclusive	24	24	
Overlap	1	1