Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Within gene all tissues Exclusive	GWAS	7.11e-01	1.42e-01	9.75e-02	2.57e-03
GWAS Exclusive	Within gene all tissues	4.94e-02	8.29e-01	6.64e-02	3.14e-01
Within gene all tissues Exclusive	GWAS Exclusive	5.80e-01	8.75e-02	9.90e-02	2.24e-03
GWAS Exclusive	Within gene all tissues Exclusive	4.28e-02	7.46e-01	4.94e-02	3.16e-01
Within gene all tissues Exclusive	Overlap	3.37e-01	4.75e-01	7.33e-01	6.53e-01
GWAS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.64e-02	1.41e-02	6.48e-02	1.45e-03



Evaluating how well Within gene all tissues genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Within gene all tissues Exclusive	GWAS	0.69	0.48	1.56	1.23	3.21
GWAS Exclusive	Within gene all tissues	0.52	-0.29	-0.45	-0.16	0.63
Within gene all tissues Exclusive	GWAS Exclusive	0.70	0.57	2.03	0.93	2.86
GWAS Exclusive	Within gene all tissues Exclusive	0.52	-0.35	-0.69	-0.11	0.62
Within gene all tissues Exclusive	Overlap	0.38	-1.11	-0.80	-0.65	-0.45
GWAS Exclusive	Overlap	1.00	2.33	1.54	1.92	1.70
Overlap	Exclusives	0.59	1.65	2.78	1.28	3.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Within gene all tissues Exclusive	GWAS	0.00	-0.37	0.55	0.27	0.57
GWAS Exclusive	Within gene all tissues	0.01	0.76	0.59	0.66	0.67
Within gene all tissues Exclusive	GWAS Exclusive	0.00	-0.32	0.90	0.08	1.12
GWAS Exclusive	Within gene all tissues Exclusive	0.01	0.25	-0.10	0.55	0.23
Within gene all tissues Exclusive	Overlap	0.00	-0.48	-0.63	-0.57	-0.37
GWAS Exclusive	Overlap	0.01	65.17	12.94	14.01	17.64
Overlap	Exclusives	0.01	3.02	3.94	1.98	4.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Within gene all tissues Exclusive	125	124	IQANK1
GWAS Exclusive	24	24	
Overlap	1	1