Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Within gene all tissues Exclusive	Lambert	8.62e-01	9.93e-01	4.31e-01	1.71e-02
Lambert Exclusive	Within gene all tissues	1.62e-01	3.68e-01	8.32e-03	2.34e-01
Within gene all tissues Exclusive	Lambert Exclusive	9.78e-01	8.87e-01	3.42e-01	1.55e-02
Lambert Exclusive	Within gene all tissues Exclusive	3.16e-01	6.21e-01	2.55e-02	3.67e-01
Within gene all tissues Exclusive	Overlap	1.18e-02	1.18e-02	5.20e-02	2.59e-01
Lambert Exclusive	Overlap	9.85e-05	3.55e-03	9.85e-05	5.91e-04
Overlap	Exclusives	4.96e-03	3.21e-06	8.40e-07	2.20e-09



Evaluating how well Within gene all tissues genes are linked to Lambert genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Within gene all tissues Exclusive	Lambert	0.58	-0.52	0.16	0.35	2.89
Lambert Exclusive	Within gene all tissues	0.54	1.67	0.69	1.03	1.68
Within gene all tissues Exclusive	Lambert Exclusive	0.59	-0.40	0.50	0.51	2.93
Lambert Exclusive	Within gene all tissues Exclusive	0.53	1.21	0.44	0.66	1.26
Within gene all tissues Exclusive	Overlap	0.27	-2.24	-2.49	-2.10	-1.05
Lambert Exclusive	Overlap	0.99	2.71	2.12	2.37	2.49
Overlap	Exclusives	0.63	2.03	5.14	2.27	6.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Within gene all tissues Exclusive	Lambert	0.01	-0.34	0.79	0.43	2.27
Lambert Exclusive	Within gene all tissues	0.01	1.45	1.21	2.48	0.93
Within gene all tissues Exclusive	Lambert Exclusive	0.01	-0.25	1.21	0.38	2.60
Lambert Exclusive	Within gene all tissues Exclusive	0.01	0.75	-0.15	0.55	0.30
Within gene all tissues Exclusive	Overlap	0.00	-0.68	-1.09	-0.65	-0.29
Lambert Exclusive	Overlap	0.03	338.33	58.20	144.50	26.15
Overlap	Exclusives	0.02	5.69	13.75	5.94	13.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Within gene all tissues Exclusive	124	123	IQANK1
Lambert Exclusive	100	94	APT8B4;MS4A;TNSF13;AC074212.3;IGH;TNSF12
Overlap	2	2