Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	3.79e-01	7.63e-03	1.64e-06	9.03e-07
GS_11 Exclusive	Cauchy_Fill_099	2.06e-03	2.15e-02	1.28e-11	2.35e-10
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	3.09e-01	5.37e-02	1.39e-04	2.69e-05
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	1.21e-02	3.20e-02	3.59e-11	2.32e-09
Cauchy_Fill_099 Exclusive	Overlap	1.75e-01	1.04e-01	2.61e-03	3.86e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.57e-01	3.41e-01	2.02e-12	2.11e-09



Evaluating how well Cauchy_Fill_099 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	0.87	0.81	2.86	1.81	4.63
GS_11 Exclusive	Cauchy_Fill_099	0.65	1.91	2.88	1.83	9.35
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	0.90	1.18	2.34	2.45	4.04
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	0.64	1.54	2.41	1.63	7.64
Cauchy_Fill_099 Exclusive	Overlap	0.78	-0.01	1.36	1.05	1.71
GS_11 Exclusive	Overlap	1.00	3.77	3.08	2.32	2.76
Overlap	Exclusives	0.64	1.51	1.64	0.96	6.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	0.00	0.13	1.61	1.94	2.74
GS_11 Exclusive	Cauchy_Fill_099	0.02	4.80	6.56	5.71	12.90
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	0.00	0.20	2.16	4.93	9.91
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	0.02	1.81	2.20	2.97	7.83
Cauchy_Fill_099 Exclusive	Overlap	0.00	-0.46	1.04	0.03	0.31
GS_11 Exclusive	Overlap	0.24	1624.19	365.31	261.58	116.93
Overlap	Exclusives	0.02	4.17	3.82	2.48	6.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_Fill_099 Exclusive	207	207	
GS_11 Exclusive	8	8	
Overlap	3	3