Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_No_Fill Exclusive	GS_11	6.00e-01	6.41e-02	1.09e-04	1.60e-05
GS_11 Exclusive	Cauchy_No_Fill	5.71e-03	1.36e-02	1.60e-11	4.37e-11
Cauchy_No_Fill Exclusive	GS_11 Exclusive	3.68e-01	1.56e-01	5.04e-04	1.69e-04
GS_11 Exclusive	Cauchy_No_Fill Exclusive	3.00e-02	3.92e-02	1.35e-11	1.90e-10
Cauchy_No_Fill Exclusive	Overlap	7.71e-02	2.96e-01	8.54e-03	5.65e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.64e-01	3.89e-01	2.57e-10	6.02e-10



Evaluating how well Cauchy_No_Fill genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_No_Fill Exclusive	GS_11	0.85	0.26	2.35	1.68	4.19
GS_11 Exclusive	Cauchy_No_Fill	0.67	2.02	2.62	1.75	9.96
Cauchy_No_Fill Exclusive	GS_11 Exclusive	0.89	0.94	2.41	2.21	3.92
GS_11 Exclusive	Cauchy_No_Fill Exclusive	0.66	1.50	2.54	1.91	7.21
Cauchy_No_Fill Exclusive	Overlap	0.74	-0.78	0.61	0.86	1.34
GS_11 Exclusive	Overlap	1.00	3.77	2.59	2.57	2.66
Overlap	Exclusives	0.66	1.15	1.47	1.11	7.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_No_Fill Exclusive	GS_11	0.00	-0.09	3.12	2.28	0.13
GS_11 Exclusive	Cauchy_No_Fill	0.02	5.60	5.90	7.16	15.52
Cauchy_No_Fill Exclusive	GS_11 Exclusive	0.00	0.44	3.23	5.67	2.89
GS_11 Exclusive	Cauchy_No_Fill Exclusive	0.02	1.73	1.84	3.24	8.32
Cauchy_No_Fill Exclusive	Overlap	0.00	-0.67	0.15	-0.04	-0.05
GS_11 Exclusive	Overlap	0.24	2225.74	390.01	406.06	494.85
Overlap	Exclusives	0.02	3.72	3.54	3.40	12.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_No_Fill Exclusive	175	175	
GS_11 Exclusive	8	8	
Overlap	3	3