Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	3.06e-01	9.06e-03	5.82e-07	4.65e-07
GS_11 Exclusive	Cauchy_Fill_099	2.81e-03	2.00e-02	1.03e-12	6.15e-10
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	2.60e-01	5.27e-02	9.74e-05	7.62e-05
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	1.12e-02	4.31e-02	2.90e-12	2.02e-09
Cauchy_Fill_099 Exclusive	Overlap	1.04e-01	1.70e-01	5.38e-03	1.90e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	3.86e-01	3.21e-01	1.30e-08	7.44e-10



Evaluating how well Cauchy_Fill_099 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	0.87	0.96	2.79	1.96	4.65
GS_11 Exclusive	Cauchy_Fill_099	0.65	2.09	3.20	1.53	7.20
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	0.90	1.43	2.61	2.42	3.41
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	0.64	1.74	2.43	1.76	6.21
Cauchy_Fill_099 Exclusive	Overlap	0.78	-0.23	1.16	0.76	1.82
GS_11 Exclusive	Overlap	1.00	3.91	2.75	2.87	2.60
Overlap	Exclusives	0.64	1.42	1.68	1.16	6.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_Fill_099 Exclusive	GS_11	0.00	0.14	1.60	3.36	12.89
GS_11 Exclusive	Cauchy_Fill_099	0.02	4.88	6.52	5.90	9.88
Cauchy_Fill_099 Exclusive	GS_11 Exclusive	0.00	0.39	1.59	4.17	7.55
GS_11 Exclusive	Cauchy_Fill_099 Exclusive	0.02	2.10	2.34	3.64	5.57
Cauchy_Fill_099 Exclusive	Overlap	0.00	-0.54	0.84	0.18	0.69
GS_11 Exclusive	Overlap	0.24	2011.28	293.48	391.90	820.68
Overlap	Exclusives	0.02	3.85	4.05	2.81	9.29

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_Fill_099 Exclusive	207	207	
GS_11 Exclusive	8	8	
Overlap	3	3