Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Female train eqtl Exclusive	Lambert	1.14e-07	4.62e-08	3.13e-08	1.42e-12
Lambert Exclusive	Female train eqtl	6.93e-02	4.94e-02	6.62e-04	1.22e-02
Female train eqtl Exclusive	Lambert Exclusive	5.33e-08	4.74e-08	3.60e-08	1.29e-11
Lambert Exclusive	Female train eqtl Exclusive	2.25e-01	9.73e-02	2.47e-03	4.79e-02
Female train eqtl Exclusive	Overlap	5.30e-01	4.76e-01	2.96e-01	5.84e-02
Lambert Exclusive	Overlap	8.71e-06	8.49e-02	4.36e-07	7.19e-05
Overlap	Exclusives	6.00e-04	9.01e-06	3.87e-22	1.40e-07



Evaluating how well Female train eqtl genes are linked to Lambert genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female train eqtl Exclusive	Lambert	0.71	4.10	6.31	4.01	7.67
Lambert Exclusive	Female train eqtl	0.58	2.97	1.97	2.74	2.95
Female train eqtl Exclusive	Lambert Exclusive	0.71	4.99	5.60	4.34	6.93
Lambert Exclusive	Female train eqtl Exclusive	0.56	2.78	1.52	2.20	2.27
Female train eqtl Exclusive	Overlap	0.84	1.10	1.36	1.37	2.06
Lambert Exclusive	Overlap	0.99	2.93	2.52	2.84	2.94
Overlap	Exclusives	0.62	3.11	4.68	2.40	6.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Female train eqtl Exclusive	Lambert	0.02	13.72	28.05	11.24	28.28
Lambert Exclusive	Female train eqtl	0.02	19.75	18.48	7.74	17.32
Female train eqtl Exclusive	Lambert Exclusive	0.02	15.86	24.26	15.00	11.26
Lambert Exclusive	Female train eqtl Exclusive	0.01	16.60	14.84	16.73	14.49
Female train eqtl Exclusive	Overlap	0.01	16.59	38.58	15.83	7.93
Lambert Exclusive	Overlap	0.01	4.37	22.40	40.15	26.11
Overlap	Exclusives	0.02	12.06	17.50	7.09	12.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Female train eqtl Exclusive	113	112	CLEC20A
Lambert Exclusive	99	93	AC074212.3;TNSF12;IGH;MS4A;APT8B4;TNSF13
Overlap	3	3