Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_2_1e4	GS_11	2.12e-02	5.36e-03	2.42e-03	3.58e-05
GS_11	Cauchy_2_1e4	9.70e-01	9.92e-01	2.14e-01	3.94e-01



Evaluating how well Cauchy_2_1e4 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_1e4	GS_11	0.82	1.84	3.00	1.69	3.62
GS_11	Cauchy_2_1e4	0.52	0.74	-0.13	-0.01	0.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_1e4	GS_11	0.00	1.57	1.60	1.09	0.97
GS_11	Cauchy_2_1e4	0.00	1.11	1.01	0.50	0.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_2_1e4	38	38	
GS_11	11	11