Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_Epilepsy	meta_GWAS	7.04e-02	7.91e-02	5.90e-02	4.25e-01
meta_GWAS	UKB_Epilepsy	1.19e-01	7.25e-01	6.10e-01	8.28e-01



Evaluating how well UKB_Epilepsy genes are linked to meta_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_Epilepsy	meta_GWAS	0.55	-0.33	-0.70	-0.38	1.19
meta_GWAS	UKB_Epilepsy	0.52	0.18	0.16	0.06	0.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_Epilepsy	meta_GWAS	0.00	1.36	0.78	0.62	0.76
meta_GWAS	UKB_Epilepsy	0.00	0.13	0.34	0.27	-0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_Epilepsy	63	60	;KDM5D;DPEP2NB
meta_GWAS	29	29