Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_2_1e-6	GeneGroup2	2.22e-01	3.38e-02	2.60e-03	1.83e-04
GeneGroup2	Cauchy_2_1e-6	3.32e-01	4.60e-01	6.51e-01	9.52e-01



Evaluating how well Cauchy_2_1e-6 genes are linked to GeneGroup2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_1e-6	GeneGroup2	0.80	0.72	1.86	0.98	3.43
GeneGroup2	Cauchy_2_1e-6	0.54	-0.53	-1.25	-0.44	0.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_1e-6	GeneGroup2	0.00	-0.04	0.53	0.14	0.36
GeneGroup2	Cauchy_2_1e-6	0.00	0.37	-0.35	0.29	0.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_2_1e-6	12	12	
GeneGroup2	11	11