Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_2_5e-8	GS_11	2.70e-04	2.00e-02	1.55e-02	2.47e-02
GS_11	Cauchy_2_5e-8	2.03e-02	3.48e-02	3.96e-01	6.50e-01



Evaluating how well Cauchy_2_5e-8 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_5e-8	GS_11	0.61	-2.30	-1.66	-1.53	0.97
GS_11	Cauchy_2_5e-8	0.51	-1.69	-1.87	-1.58	0.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_2_5e-8	GS_11	0.00	-0.97	-1.35	-0.84	-0.22
GS_11	Cauchy_2_5e-8	0.00	-0.94	-0.87	-0.59	-0.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_2_5e-8	6	6	
GS_11	11	11