Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
brain all Exclusive	lambert	6.35e-01	8.64e-01	7.06e-02	1.41e-02
lambert Exclusive	brain all	1.99e-02	5.52e-01	6.52e-02	3.17e-01
brain all Exclusive	lambert Exclusive	6.68e-01	7.41e-01	6.67e-02	1.09e-02
lambert Exclusive	brain all Exclusive	1.16e-02	5.04e-01	9.92e-02	4.32e-01
brain all Exclusive	Overlap	7.52e-01	4.55e-01	9.90e-01	8.12e-01
lambert Exclusive	Overlap	1.98e-02	3.96e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.71e-05	1.05e-04	1.21e-05	2.73e-06



Evaluating how well brain all genes are linked to lambert genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
brain all Exclusive	lambert	0.59	-0.51	0.23	0.40	2.84
lambert Exclusive	brain all	0.53	-0.36	-0.25	0.00	1.44
brain all Exclusive	lambert Exclusive	0.59	-0.57	0.31	0.43	2.88
lambert Exclusive	brain all Exclusive	0.52	-0.53	-0.38	-0.37	1.08
brain all Exclusive	Overlap	0.41	-0.45	-0.75	-0.40	-0.37
lambert Exclusive	Overlap	0.99	2.00	1.89	2.07	1.79
Overlap	Exclusives	0.60	1.76	3.90	1.57	6.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
brain all Exclusive	lambert	0.01	0.10	1.01	0.85	1.79
lambert Exclusive	brain all	0.01	0.36	0.51	1.03	1.85
brain all Exclusive	lambert Exclusive	0.01	0.32	1.42	0.87	4.46
lambert Exclusive	brain all Exclusive	0.01	-0.01	0.05	0.78	2.08
brain all Exclusive	Overlap	0.00	-0.45	-0.34	-0.15	-0.13
lambert Exclusive	Overlap	0.00	9.74	7.05	9.69	11.78
Overlap	Exclusives	0.02	2.78	7.53	2.45	8.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
brain all Exclusive	164	163	IGHD
lambert Exclusive	101	95	MS4A;IGH;TNSF12;APT8B4;TNSF13;AC074212.3
Overlap	1	1