Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
brain all Exclusive	gwas	1.13e-01	2.91e-01	7.60e-01	2.23e-01
gwas Exclusive	brain all	1.56e-02	4.78e-01	4.97e-01	6.23e-01
brain all Exclusive	gwas Exclusive	1.14e-01	2.31e-01	7.21e-01	6.94e-02
gwas Exclusive	brain all Exclusive	1.85e-02	5.75e-01	5.69e-01	7.91e-01
brain all Exclusive	Overlap	7.52e-01	3.96e-01	7.92e-01	8.12e-01
gwas Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	5.94e-02
Overlap	Exclusives	4.00e-04	5.68e-02	5.37e-03	7.66e-03



Evaluating how well brain all genes are linked to gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
brain all Exclusive	gwas	0.60	-1.28	-1.06	-0.31	1.58
gwas Exclusive	brain all	0.52	-1.42	-0.84	-0.54	1.03
brain all Exclusive	gwas Exclusive	0.61	-1.33	-0.94	-0.37	2.04
gwas Exclusive	brain all Exclusive	0.52	-1.33	-0.87	-0.66	0.69
brain all Exclusive	Overlap	0.41	-0.46	-0.98	-0.46	-0.37
gwas Exclusive	Overlap	1.00	2.08	1.56	1.91	1.68
Overlap	Exclusives	0.57	1.31	1.77	1.30	3.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
brain all Exclusive	gwas	0.00	-0.80	-1.12	-0.37	0.94
gwas Exclusive	brain all	0.01	-0.89	-0.79	-0.24	0.90
brain all Exclusive	gwas Exclusive	0.00	-0.88	-1.02	-0.42	0.43
gwas Exclusive	brain all Exclusive	0.01	-1.05	-0.97	-0.40	0.33
brain all Exclusive	Overlap	0.00	-0.22	-0.31	-0.39	-0.30
gwas Exclusive	Overlap	0.01	25.58	16.79	9.50	3.26
Overlap	Exclusives	0.01	2.55	2.60	2.63	5.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
brain all Exclusive	164	163	IGHD
gwas Exclusive	24	24	
Overlap	1	1