Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_5e8 Exclusive	GS_11	6.31e-01	7.07e-02	3.46e-05	3.23e-05
GS_11 Exclusive	Combined_5e8	8.73e-03	7.26e-02	2.84e-11	5.41e-11
Combined_5e8 Exclusive	GS_11 Exclusive	5.51e-01	2.75e-01	9.90e-04	5.40e-04
GS_11 Exclusive	Combined_5e8 Exclusive	3.79e-02	1.25e-01	2.62e-10	2.41e-10
Combined_5e8 Exclusive	Overlap	5.84e-02	2.89e-01	2.09e-02	8.78e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.63e-01	4.82e-01	7.40e-09	1.06e-09



Evaluating how well Combined_5e8 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_5e8 Exclusive	GS_11	0.84	0.12	2.00	2.00	4.02
GS_11 Exclusive	Combined_5e8	0.66	1.86	2.60	1.81	8.08
Combined_5e8 Exclusive	GS_11 Exclusive	0.88	0.92	2.25	2.09	4.03
GS_11 Exclusive	Combined_5e8 Exclusive	0.66	1.31	2.11	1.46	7.06
Combined_5e8 Exclusive	Overlap	0.72	-1.23	0.60	0.61	1.21
GS_11 Exclusive	Overlap	1.00	3.82	2.67	2.98	2.91
Overlap	Exclusives	0.66	1.02	1.54	0.80	6.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_5e8 Exclusive	GS_11	0.00	-0.28	2.01	3.57	2.14
GS_11 Exclusive	Combined_5e8	0.02	4.76	5.79	7.41	11.69
Combined_5e8 Exclusive	GS_11 Exclusive	0.00	0.03	2.32	3.66	10.38
GS_11 Exclusive	Combined_5e8 Exclusive	0.02	1.71	1.35	2.81	8.48
Combined_5e8 Exclusive	Overlap	0.00	-0.65	-0.00	-0.13	-0.11
GS_11 Exclusive	Overlap	0.24	2022.76	292.03	663.26	403.07
Overlap	Exclusives	0.02	3.27	3.65	2.19	5.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_5e8 Exclusive	181	181	
GS_11 Exclusive	8	8	
Overlap	3	3