Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_1e6 Exclusive	GS_11	5.50e-01	3.51e-02	4.49e-06	5.25e-06
GS_11 Exclusive	Combined_1e6	7.86e-03	4.40e-02	4.36e-13	4.67e-10
Combined_1e6 Exclusive	GS_11 Exclusive	5.22e-01	1.13e-01	3.54e-04	1.45e-04
GS_11 Exclusive	Combined_1e6 Exclusive	3.02e-02	1.05e-01	3.00e-10	1.69e-10
Combined_1e6 Exclusive	Overlap	6.83e-02	2.10e-01	1.21e-02	3.19e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	4.66e-01	4.26e-01	1.11e-10	3.20e-10



Evaluating how well Combined_1e6 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_1e6 Exclusive	GS_11	0.86	0.38	2.55	1.84	4.68
GS_11 Exclusive	Combined_1e6	0.66	1.93	2.59	2.14	7.52
Combined_1e6 Exclusive	GS_11 Exclusive	0.89	1.19	2.42	2.04	4.24
GS_11 Exclusive	Combined_1e6 Exclusive	0.65	1.39	2.00	1.54	7.11
Combined_1e6 Exclusive	Overlap	0.76	-0.46	1.09	0.73	1.69
GS_11 Exclusive	Overlap	1.00	3.48	2.61	3.14	3.40
Overlap	Exclusives	0.65	1.28	1.63	0.88	7.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_1e6 Exclusive	GS_11	0.00	-0.17	2.15	2.02	4.04
GS_11 Exclusive	Combined_1e6	0.02	5.01	5.52	7.97	13.29
Combined_1e6 Exclusive	GS_11 Exclusive	0.00	0.19	1.90	3.30	1.93
GS_11 Exclusive	Combined_1e6 Exclusive	0.02	1.64	1.78	2.85	8.43
Combined_1e6 Exclusive	Overlap	0.00	-0.62	0.61	-0.06	0.22
GS_11 Exclusive	Overlap	0.24	1334.81	321.05	811.90	970.18
Overlap	Exclusives	0.02	3.77	3.47	2.60	8.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_1e6 Exclusive	187	187	
GS_11 Exclusive	8	8	
Overlap	3	3