Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Combined_1e5 Exclusive	GS_11	5.35e-01	6.70e-03	1.44e-07	8.28e-07
GS_11 Exclusive	Combined_1e5	4.43e-03	5.08e-02	7.52e-12	9.19e-11
Combined_1e5 Exclusive	GS_11 Exclusive	4.83e-01	4.29e-02	9.74e-05	7.31e-05
GS_11 Exclusive	Combined_1e5 Exclusive	1.19e-02	8.54e-02	1.11e-12	6.70e-10
Combined_1e5 Exclusive	Overlap	1.00e-01	8.78e-02	2.96e-04	3.19e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.10e-01	3.50e-01	2.97e-08	2.30e-10



Evaluating how well Combined_1e5 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_1e5 Exclusive	GS_11	0.87	0.65	2.87	2.28	4.52
GS_11 Exclusive	Combined_1e5	0.66	1.86	2.58	1.88	8.26
Combined_1e5 Exclusive	GS_11 Exclusive	0.90	1.08	2.83	2.44	4.47
GS_11 Exclusive	Combined_1e5 Exclusive	0.66	1.58	2.20	1.54	7.26
Combined_1e5 Exclusive	Overlap	0.80	-0.15	1.43	1.28	1.90
GS_11 Exclusive	Overlap	1.00	4.00	2.72	2.44	3.01
Overlap	Exclusives	0.66	1.41	1.89	1.13	7.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Combined_1e5 Exclusive	GS_11	0.00	-0.09	2.19	2.66	6.76
GS_11 Exclusive	Combined_1e5	0.02	5.06	6.23	7.56	14.17
Combined_1e5 Exclusive	GS_11 Exclusive	0.00	0.26	1.89	6.28	3.20
GS_11 Exclusive	Combined_1e5 Exclusive	0.02	2.24	1.99	2.33	7.96
Combined_1e5 Exclusive	Overlap	0.00	-0.52	1.19	0.65	0.17
GS_11 Exclusive	Overlap	0.24	2478.59	441.56	711.35	127.08
Overlap	Exclusives	0.02	4.19	4.09	3.09	14.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Combined_1e5 Exclusive	192	192	
GS_11 Exclusive	8	8	
Overlap	3	3