Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Cauchy_3_2_5e8 Exclusive	GS_11	5.35e-01	4.42e-02	9.28e-05	2.82e-05
GS_11 Exclusive	Cauchy_3_2_5e8	1.15e-02	7.90e-02	3.18e-12	1.13e-11
Cauchy_3_2_5e8 Exclusive	GS_11 Exclusive	6.27e-01	2.88e-01	8.12e-04	3.80e-04
GS_11 Exclusive	Cauchy_3_2_5e8 Exclusive	4.51e-02	1.39e-01	8.85e-14	3.52e-10
Cauchy_3_2_5e8 Exclusive	Overlap	3.58e-02	3.82e-01	2.38e-02	8.78e-02
GS_11 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	5.66e-01	4.90e-01	4.59e-08	9.32e-10



Evaluating how well Cauchy_3_2_5e8 genes are linked to GS_11 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_3_2_5e8 Exclusive	GS_11	0.84	-0.05	2.39	1.81	3.91
GS_11 Exclusive	Cauchy_3_2_5e8	0.66	1.96	2.34	1.88	7.29
Cauchy_3_2_5e8 Exclusive	GS_11 Exclusive	0.88	0.91	1.99	1.81	3.99
GS_11 Exclusive	Cauchy_3_2_5e8 Exclusive	0.66	1.38	1.87	1.80	7.88
Cauchy_3_2_5e8 Exclusive	Overlap	0.72	-1.40	0.40	0.48	1.12
GS_11 Exclusive	Overlap	1.00	3.46	2.86	2.44	3.04
Overlap	Exclusives	0.66	1.15	1.41	0.81	7.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Cauchy_3_2_5e8 Exclusive	GS_11	0.00	-0.42	2.46	2.72	3.82
GS_11 Exclusive	Cauchy_3_2_5e8	0.02	5.61	5.38	7.52	16.13
Cauchy_3_2_5e8 Exclusive	GS_11 Exclusive	0.00	-0.01	2.24	3.48	0.64
GS_11 Exclusive	Cauchy_3_2_5e8 Exclusive	0.02	1.61	1.60	3.63	10.24
Cauchy_3_2_5e8 Exclusive	Overlap	0.00	-0.76	-0.21	-0.17	-0.12
GS_11 Exclusive	Overlap	0.24	1654.83	377.87	281.68	197.90
Overlap	Exclusives	0.02	3.56	3.28	2.54	6.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Cauchy_3_2_5e8 Exclusive	181	181	
GS_11 Exclusive	8	8	
Overlap	3	3