Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
5k splice 29 Exclusive	ad gwas	2.65e-03	1.53e-02	7.49e-03	6.19e-05
ad gwas Exclusive	5k splice 29	9.37e-01	2.90e-02	5.75e-03	2.08e-03
5k splice 29 Exclusive	ad gwas Exclusive	3.20e-03	1.93e-02	3.41e-03	5.21e-04
ad gwas Exclusive	5k splice 29 Exclusive	8.02e-01	7.18e-02	7.85e-03	4.44e-03
5k splice 29 Exclusive	Overlap	2.41e-01	6.85e-01	2.68e-01	5.47e-02
ad gwas Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.61e-02	1.05e-02	7.94e-15	2.46e-03



Evaluating how well 5k splice 29 genes are linked to ad gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5k splice 29 Exclusive	ad gwas	0.76	3.11	3.42	1.74	4.06
ad gwas Exclusive	5k splice 29	0.57	1.51	2.05	1.57	2.68
5k splice 29 Exclusive	ad gwas Exclusive	0.75	2.60	3.11	2.18	4.00
ad gwas Exclusive	5k splice 29 Exclusive	0.56	1.19	1.77	1.21	2.79
5k splice 29 Exclusive	Overlap	0.87	2.23	1.31	1.46	2.27
ad gwas Exclusive	Overlap	1.00	2.96	2.27	3.24	3.41
Overlap	Exclusives	0.59	3.00	3.32	1.75	4.52

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
5k splice 29 Exclusive	ad gwas	0.00	4.33	2.35	1.29	1.90
ad gwas Exclusive	5k splice 29	0.01	3.63	4.74	3.30	2.26
5k splice 29 Exclusive	ad gwas Exclusive	0.00	1.94	3.15	2.24	1.99
ad gwas Exclusive	5k splice 29 Exclusive	0.01	1.19	2.40	0.74	1.45
5k splice 29 Exclusive	Overlap	0.00	0.92	0.93	0.54	3.92
ad gwas Exclusive	Overlap	0.03	58.62	54.68	197.58	273.14
Overlap	Exclusives	0.03	24.86	24.14	16.29	15.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
5k splice 29 Exclusive	141	141	
ad gwas Exclusive	22	22	
Overlap	3	3