Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC splice 29 Exclusive	ad gwas	4.98e-01	8.21e-02	6.94e-01	7.80e-02
ad gwas Exclusive	ADC splice 29	6.14e-01	1.76e-01	7.66e-02	6.57e-02
ADC splice 29 Exclusive	ad gwas Exclusive	8.02e-01	3.43e-01	8.28e-01	1.74e-01
ad gwas Exclusive	ADC splice 29 Exclusive	4.92e-01	4.22e-01	1.39e-01	1.63e-01
ADC splice 29 Exclusive	Overlap	6.31e-01	1.37e-01	6.13e-01	8.81e-01
ad gwas Exclusive	Overlap	1.83e-09	1.83e-06	1.83e-09	9.14e-09
Overlap	Exclusives	1.44e-01	7.31e-02	7.92e-12	3.18e-03



Evaluating how well ADC splice 29 genes are linked to ad gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC splice 29 Exclusive	ad gwas	0.58	-0.39	-1.75	-0.54	1.57
ad gwas Exclusive	ADC splice 29	0.56	1.08	1.62	1.33	2.31
ADC splice 29 Exclusive	ad gwas Exclusive	0.59	-0.13	-0.68	-0.36	1.27
ad gwas Exclusive	ADC splice 29 Exclusive	0.54	0.41	0.96	0.74	1.52
ADC splice 29 Exclusive	Overlap	0.58	-1.46	-3.11	-1.17	0.45
ad gwas Exclusive	Overlap	1.00	3.45	3.07	3.31	3.95
Overlap	Exclusives	0.61	2.47	3.86	2.35	4.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC splice 29 Exclusive	ad gwas	0.00	-0.48	-1.61	-0.57	0.35
ad gwas Exclusive	ADC splice 29	0.01	1.73	4.49	3.82	5.04
ADC splice 29 Exclusive	ad gwas Exclusive	0.00	-0.23	-0.68	-0.43	-0.09
ad gwas Exclusive	ADC splice 29 Exclusive	0.01	-0.53	0.26	-0.14	0.34
ADC splice 29 Exclusive	Overlap	0.00	-0.50	-1.50	-0.61	-0.18
ad gwas Exclusive	Overlap	0.06	215.23	45.83	251.04	193.83
Overlap	Exclusives	0.04	44.63	64.74	26.17	53.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC splice 29 Exclusive	106	105	MFRP
ad gwas Exclusive	21	21	
Overlap	4	4