Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LOAD splice 29 Exclusive	Lambert	5.69e-01	5.78e-01	8.10e-01	2.95e-01
Lambert Exclusive	LOAD splice 29	5.99e-03	1.63e-01	3.85e-01	9.47e-02
LOAD splice 29 Exclusive	Lambert Exclusive	2.91e-01	5.56e-01	7.58e-01	3.36e-01
Lambert Exclusive	LOAD splice 29 Exclusive	4.81e-03	1.43e-01	4.93e-01	1.35e-01
LOAD splice 29 Exclusive	Overlap	5.94e-01	8.32e-01	7.92e-01	8.51e-01
Lambert Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	7.92e-02
Overlap	Exclusives	3.95e-01	1.41e-02	5.95e-06	5.25e-07



Evaluating how well LOAD splice 29 genes are linked to Lambert genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LOAD splice 29 Exclusive	Lambert	0.55	-0.69	-1.24	-0.87	1.59
Lambert Exclusive	LOAD splice 29	0.52	0.06	-0.37	-0.21	1.18
LOAD splice 29 Exclusive	Lambert Exclusive	0.55	-0.98	-1.14	-0.84	1.73
Lambert Exclusive	LOAD splice 29 Exclusive	0.52	-0.09	-0.63	-0.49	0.71
LOAD splice 29 Exclusive	Overlap	0.40	0.36	0.02	0.03	-0.21
Lambert Exclusive	Overlap	0.96	2.70	2.73	2.09	1.52
Overlap	Exclusives	0.58	1.46	2.26	1.07	4.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LOAD splice 29 Exclusive	Lambert	0.01	-0.78	-0.92	-0.87	0.86
Lambert Exclusive	LOAD splice 29	0.01	-0.34	-0.63	-0.49	-0.07
LOAD splice 29 Exclusive	Lambert Exclusive	0.01	-0.93	-0.91	-0.78	0.37
Lambert Exclusive	LOAD splice 29 Exclusive	0.01	-0.51	-0.97	-0.78	-0.37
LOAD splice 29 Exclusive	Overlap	0.00	-0.14	-0.28	-0.25	-0.43
Lambert Exclusive	Overlap	0.00	8.91	12.72	6.15	0.91
Overlap	Exclusives	0.02	1.62	3.19	1.18	5.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LOAD splice 29 Exclusive	131	131	
Lambert Exclusive	101	95	TNSF13;TNSF12;MS4A;IGH;APT8B4;AC074212.3
Overlap	1	1