Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
R4_EUR_FDR01 Exclusive	Tier1	7.25e-02	1.10e-01	6.98e-02	8.52e-04
Tier1 Exclusive	R4_EUR_FDR01	4.83e-01	5.40e-01	1.64e-01	1.45e-01
R4_EUR_FDR01 Exclusive	Tier1 Exclusive	5.82e-02	1.40e-01	7.17e-02	4.05e-03
Tier1 Exclusive	R4_EUR_FDR01 Exclusive	3.03e-01	7.07e-01	1.83e-01	1.73e-01
R4_EUR_FDR01 Exclusive	Overlap	7.89e-01	7.31e-01	7.13e-01	3.50e-01
Tier1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.59e-04	8.68e-06	2.13e-15	6.39e-08



Evaluating how well R4_EUR_FDR01 genes are linked to Tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR01 Exclusive	Tier1	0.71	2.84	2.29	1.77	4.08
Tier1 Exclusive	R4_EUR_FDR01	0.56	0.77	1.48	1.31	2.34
R4_EUR_FDR01 Exclusive	Tier1 Exclusive	0.70	2.53	2.18	1.56	3.41
Tier1 Exclusive	R4_EUR_FDR01 Exclusive	0.55	0.23	0.82	1.00	1.49
R4_EUR_FDR01 Exclusive	Overlap	0.76	0.98	0.70	0.96	1.33
Tier1 Exclusive	Overlap	1.00	3.49	2.89	2.30	3.05
Overlap	Exclusives	0.67	4.19	7.09	3.59	6.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR01 Exclusive	Tier1	0.00	2.99	1.26	1.68	1.49
Tier1 Exclusive	R4_EUR_FDR01	0.01	5.24	7.82	3.08	2.33
R4_EUR_FDR01 Exclusive	Tier1 Exclusive	0.00	1.88	1.45	0.72	1.83
Tier1 Exclusive	R4_EUR_FDR01 Exclusive	0.01	0.55	0.65	0.63	1.56
R4_EUR_FDR01 Exclusive	Overlap	0.00	3.10	4.79	5.95	2.13
Tier1 Exclusive	Overlap	0.04	125.27	189.68	142.24	41.73
Overlap	Exclusives	0.03	18.22	21.69	23.93	16.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
R4_EUR_FDR01 Exclusive	93	91	EDDM13;AC006059.2
Tier1 Exclusive	27	26	MS4A
Overlap	4	3