Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS	2.28e-01	2.21e-01	1.08e-01	4.71e-03
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5	4.14e-01	2.91e-01	1.15e-01	1.12e-01
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS Exclusive	1.98e-01	3.28e-01	1.30e-01	6.31e-03
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5 Exclusive	4.33e-01	3.28e-01	4.99e-02	2.09e-01
EUR_stats_related_clean_AD_z_3_5 Exclusive	Overlap	7.89e-01	7.89e-01	7.89e-01	4.15e-01
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	6.62e-03	8.03e-05	4.00e-15	1.88e-06



Evaluating how well EUR_stats_related_clean_AD_z_3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS	0.68	0.99	1.80	1.42	3.99
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5	0.54	1.09	1.37	1.28	1.81
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS Exclusive	0.67	1.02	1.55	1.20	3.13
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5 Exclusive	0.53	0.96	1.15	1.16	1.59
EUR_stats_related_clean_AD_z_3_5 Exclusive	Overlap	0.75	1.03	0.62	0.72	1.33
TIER1_GS Exclusive	Overlap	1.00	2.98	2.43	2.73	3.02
Overlap	Exclusives	0.61	4.55	5.95	3.25	5.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS	0.00	1.58	2.66	2.13	4.99
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5	0.01	2.95	2.21	3.83	4.06
EUR_stats_related_clean_AD_z_3_5 Exclusive	TIER1_GS Exclusive	0.00	1.17	1.42	2.05	3.34
TIER1_GS Exclusive	EUR_stats_related_clean_AD_z_3_5 Exclusive	0.01	0.94	0.36	1.18	1.30
EUR_stats_related_clean_AD_z_3_5 Exclusive	Overlap	0.00	2.83	11.32	6.74	6.17
TIER1_GS Exclusive	Overlap	0.04	85.09	135.65	79.08	20.62
Overlap	Exclusives	0.03	14.54	11.73	10.74	23.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EUR_stats_related_clean_AD_z_3_5 Exclusive	182	178	AC006059.2;EDDM13;AC093512.2;TM9SF1
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3