Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
R4_EUR_FDR01	GS_14	3.78e-01	3.53e-01	1.86e-01	1.56e-02
GS_14	R4_EUR_FDR01	6.15e-01	2.52e-01	1.45e-04	2.86e-02



Evaluating how well R4_EUR_FDR01 genes are linked to GS_14 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR01	GS_14	0.74	1.06	1.57	0.97	2.90
GS_14	R4_EUR_FDR01	0.59	3.89	2.44	2.07	3.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR01	GS_14	0.01	5.67	3.11	4.41	13.01
GS_14	R4_EUR_FDR01	0.01	2.23	2.26	1.75	3.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
R4_EUR_FDR01	97	94	;AC006059.2;EDDM13
GS_14	14	14