Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
R4_EUR_FDR0001 Exclusive	Tier1	8.44e-01	5.95e-01	8.70e-01	1.80e-01
Tier1 Exclusive	R4_EUR_FDR0001	4.37e-01	8.95e-01	5.05e-01	4.94e-01
R4_EUR_FDR0001 Exclusive	Tier1 Exclusive	9.39e-01	3.70e-01	5.30e-01	3.68e-01
Tier1 Exclusive	R4_EUR_FDR0001 Exclusive	1.45e-01	9.69e-01	9.02e-01	6.82e-01
R4_EUR_FDR0001 Exclusive	Overlap	2.75e-01	4.85e-01	1.86e-01	3.86e-02
Tier1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.59e-06	2.77e-07	2.85e-13	2.18e-08



Evaluating how well R4_EUR_FDR0001 genes are linked to Tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR0001 Exclusive	Tier1	0.58	0.35	-0.95	-0.24	1.46
Tier1 Exclusive	R4_EUR_FDR0001	0.55	0.02	0.60	0.73	1.18
R4_EUR_FDR0001 Exclusive	Tier1 Exclusive	0.55	0.29	-1.25	-0.58	0.71
Tier1 Exclusive	R4_EUR_FDR0001 Exclusive	0.51	-0.63	-0.12	-0.16	0.37
R4_EUR_FDR0001 Exclusive	Overlap	0.83	1.29	1.17	1.53	1.92
Tier1 Exclusive	Overlap	1.00	2.83	2.47	2.60	3.11
Overlap	Exclusives	0.73	5.27	6.60	4.36	6.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R4_EUR_FDR0001 Exclusive	Tier1	0.00	-0.02	-1.19	-0.33	0.09
Tier1 Exclusive	R4_EUR_FDR0001	0.01	5.92	9.24	3.50	3.25
R4_EUR_FDR0001 Exclusive	Tier1 Exclusive	0.00	-0.14	-1.19	-0.66	-0.23
Tier1 Exclusive	R4_EUR_FDR0001 Exclusive	0.00	-0.78	-0.52	-0.43	-0.32
R4_EUR_FDR0001 Exclusive	Overlap	0.00	0.58	-0.30	0.47	0.31
Tier1 Exclusive	Overlap	0.04	107.52	142.67	120.07	116.24
Overlap	Exclusives	0.04	10.94	73.67	43.46	20.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
R4_EUR_FDR0001 Exclusive	43	42	AC006059.2
Tier1 Exclusive	27	26	MS4A
Overlap	4	3