Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25	2.74e-05	2.53e-05	1.16e-06	2.70e-07
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl	1.18e-01	4.13e-02	3.47e-03	4.88e-03
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25 Exclusive	4.76e-06	4.65e-06	3.66e-07	9.69e-08
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	1.97e-01	3.38e-02	8.05e-03	3.68e-03
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	Overlap	7.89e-01	7.89e-01	7.89e-01	4.32e-01
ad_gs_25 Exclusive	Overlap	7.71e-02	7.71e-02	7.71e-02	7.96e-02
Overlap	Exclusives	1.61e-02	1.42e-03	1.92e-22	6.11e-06



Evaluating how well All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25	0.83	3.30	4.76	3.09	5.25
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl	0.60	2.03	2.19	2.67	3.36
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25 Exclusive	0.84	3.85	5.48	3.05	6.47
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	0.59	2.28	2.53	2.21	3.75
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	Overlap	0.75	0.50	0.83	0.69	1.45
ad_gs_25 Exclusive	Overlap	0.84	2.17	0.78	1.48	1.91
Overlap	Exclusives	0.64	3.68	5.12	2.60	6.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25	0.03	23.58	9.20	34.35	42.23
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl	0.01	3.62	6.34	6.26	11.21
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	ad_gs_25 Exclusive	0.02	29.67	13.78	28.42	13.69
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	0.01	3.73	3.31	6.76	8.84
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	Overlap	0.02	31.09	144.78	58.64	13.01
ad_gs_25 Exclusive	Overlap	0.01	42.60	22.57	64.83	23.18
Overlap	Exclusives	0.02	8.82	16.22	5.59	10.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_eqtl Exclusive	109	108	CLEC20A
ad_gs_25 Exclusive	22	22	
Overlap	3	3