Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 6.47e-01 7.41e-01 7.44e-01 1.44e-01 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai 7.40e-01 3.86e-02 1.78e-02 1.04e-02 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 Exclusive 8.87e-01 7.44e-01 6.37e-01 1.21e-01 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive 5.92e-01 6.41e-02 2.28e-02 2.13e-02 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive Overlap 3.42e-01 6.12e-01 2.61e-01 1.32e-01 ad_gs_25 Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-07 Overlap Exclusives 4.04e-02 1.09e-02 1.06e-15 1.66e-03 Evaluating how well All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai genes are linked to ad_gs_25 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 0.62 0.38 -0.68 -0.05 2.28 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai 0.56 0.99 2.06 1.28 2.29 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 Exclusive 0.61 0.01 -0.31 0.02 1.88 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive 0.55 0.62 1.80 0.91 1.99 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive Overlap 0.75 0.90 -0.41 0.41 1.54 ad_gs_25 Exclusive Overlap 1.00 2.99 2.63 2.75 3.50 Overlap Exclusives 0.59 2.05 3.68 1.85 3.62 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 0.00 0.11 -0.86 -0.30 1.17 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai 0.01 1.18 2.47 0.92 1.44 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive ad_gs_25 Exclusive 0.00 -0.25 -0.66 -0.33 -0.07 ad_gs_25 Exclusive All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive 0.01 -0.49 0.60 -0.21 0.34 All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive Overlap 0.00 0.72 -0.16 0.81 2.17 ad_gs_25 Exclusive Overlap 0.03 86.53 71.14 119.79 134.72 Overlap Exclusives 0.02 18.69 24.23 9.13 16.08 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive 138 138 ad_gs_25 Exclusive 22 22 Overlap 3 3