Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All_z_2_9_spliceai Exclusive	ad_gs_25	1.95e-03	2.10e-02	5.91e-03	1.85e-05
ad_gs_25 Exclusive	All_z_2_9_spliceai	3.81e-01	4.46e-02	7.37e-03	1.03e-02
All_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	2.55e-03	2.61e-02	1.20e-02	5.30e-05
ad_gs_25 Exclusive	All_z_2_9_spliceai Exclusive	6.30e-01	1.09e-01	6.78e-03	2.30e-02
All_z_2_9_spliceai Exclusive	Overlap	2.16e-01	4.41e-01	3.34e-01	5.12e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.66e-02	1.36e-02	1.31e-17	8.45e-04



Evaluating how well All_z_2_9_spliceai genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All_z_2_9_spliceai Exclusive	ad_gs_25	0.78	3.22	4.23	2.26	4.93
ad_gs_25 Exclusive	All_z_2_9_spliceai	0.56	1.78	2.75	1.92	2.33
All_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	0.76	3.07	3.45	1.81	4.67
ad_gs_25 Exclusive	All_z_2_9_spliceai Exclusive	0.55	1.65	2.56	1.81	2.38
All_z_2_9_spliceai Exclusive	Overlap	0.86	2.17	1.47	1.47	2.42
ad_gs_25 Exclusive	Overlap	1.00	2.99	1.97	3.19	3.02
Overlap	Exclusives	0.58	3.17	2.92	2.01	3.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All_z_2_9_spliceai Exclusive	ad_gs_25	0.00	3.93	4.09	2.19	0.49
ad_gs_25 Exclusive	All_z_2_9_spliceai	0.01	3.03	6.55	2.51	3.44
All_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	0.00	5.60	3.18	1.33	4.28
ad_gs_25 Exclusive	All_z_2_9_spliceai Exclusive	0.01	1.62	3.90	1.37	1.68
All_z_2_9_spliceai Exclusive	Overlap	0.00	1.64	1.29	0.61	0.09
ad_gs_25 Exclusive	Overlap	0.03	97.40	67.97	110.51	208.65
Overlap	Exclusives	0.03	29.93	24.42	17.71	14.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All_z_2_9_spliceai Exclusive	144	144	
ad_gs_25 Exclusive	22	22	
Overlap	3	3