Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All_z_2_9_spliceai Exclusive	TIER1_GS	7.55e-03	3.95e-02	2.96e-03	1.22e-04
TIER1_GS Exclusive	All_z_2_9_spliceai	5.82e-01	2.19e-01	1.98e-01	9.67e-02
All_z_2_9_spliceai Exclusive	TIER1_GS Exclusive	9.02e-03	8.45e-02	6.75e-03	5.45e-04
TIER1_GS Exclusive	All_z_2_9_spliceai Exclusive	3.93e-01	2.35e-01	1.67e-01	9.16e-02
All_z_2_9_spliceai Exclusive	Overlap	2.04e-01	4.24e-01	4.24e-01	3.19e-02
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	3.07e-03	1.57e-03	1.14e-21	2.33e-04



Evaluating how well All_z_2_9_spliceai genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All_z_2_9_spliceai Exclusive	TIER1_GS	0.72	2.76	3.19	2.40	3.91
TIER1_GS Exclusive	All_z_2_9_spliceai	0.55	1.37	2.32	1.58	1.84
All_z_2_9_spliceai Exclusive	TIER1_GS Exclusive	0.70	2.47	3.21	1.85	3.77
TIER1_GS Exclusive	All_z_2_9_spliceai Exclusive	0.54	1.02	1.91	1.24	1.64
All_z_2_9_spliceai Exclusive	Overlap	0.86	2.08	1.36	1.65	2.40
TIER1_GS Exclusive	Overlap	1.00	3.06	2.83	2.87	3.30
Overlap	Exclusives	0.60	4.44	4.81	2.61	4.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All_z_2_9_spliceai Exclusive	TIER1_GS	0.00	4.35	3.99	2.23	6.20
TIER1_GS Exclusive	All_z_2_9_spliceai	0.01	2.23	6.57	3.24	2.80
All_z_2_9_spliceai Exclusive	TIER1_GS Exclusive	0.00	3.82	3.71	1.84	1.57
TIER1_GS Exclusive	All_z_2_9_spliceai Exclusive	0.01	1.36	2.75	1.84	1.53
All_z_2_9_spliceai Exclusive	Overlap	0.00	2.49	0.85	1.21	3.21
TIER1_GS Exclusive	Overlap	0.03	113.36	105.01	137.34	187.44
Overlap	Exclusives	0.03	37.56	41.05	25.28	39.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All_z_2_9_spliceai Exclusive	144	144	
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3