Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25	6.57e-01	9.21e-01	5.86e-01	2.12e-01
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai	7.36e-01	3.61e-02	6.22e-03	5.32e-03
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	7.58e-01	8.17e-01	8.60e-01	1.49e-01
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	4.98e-01	5.83e-02	3.69e-02	1.72e-02
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	Overlap	3.65e-01	5.66e-01	2.82e-01	1.23e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	3.95e-02	1.27e-02	6.13e-17	1.41e-03



Evaluating how well All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25	0.62	0.38	-0.42	0.07	2.08
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai	0.56	0.99	2.25	1.63	2.70
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	0.61	0.17	-0.25	-0.27	1.75
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	0.55	0.55	1.96	0.80	1.81
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	Overlap	0.75	0.59	-0.37	0.59	1.50
ad_gs_25 Exclusive	Overlap	1.00	3.41	2.15	2.64	3.31
Overlap	Exclusives	0.59	2.42	3.90	1.99	3.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25	0.00	0.19	-0.75	-0.28	0.84
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai	0.01	0.87	2.09	0.86	2.14
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	ad_gs_25 Exclusive	0.00	-0.13	-0.70	-0.57	0.16
ad_gs_25 Exclusive	All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	0.01	-0.64	0.52	-0.26	0.66
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	Overlap	0.00	0.43	-0.15	0.65	2.98
ad_gs_25 Exclusive	Overlap	0.03	87.14	60.71	134.21	50.72
Overlap	Exclusives	0.02	20.00	24.40	15.68	20.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All Excluding Young (PITT,MIA, KGAD, STEP)_z_2_9_spliceai Exclusive	138	138	
ad_gs_25 Exclusive	22	22	
Overlap	3	3