Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	4.51e-03	1.57e-02	2.99e-03	1.16e-04
ad_gs_25 Exclusive	splice_jorge_144	9.39e-01	3.83e-02	8.95e-03	2.28e-03
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	3.30e-03	1.47e-02	3.87e-03	4.94e-04
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	8.96e-01	5.40e-02	3.15e-03	5.60e-03
splice_jorge_144 Exclusive	Overlap	3.50e-01	5.84e-01	2.10e-01	6.03e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	2.20e-02	8.07e-03	1.09e-16	2.79e-03



Evaluating how well splice_jorge_144 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	0.76	2.82	4.04	2.24	4.24
ad_gs_25 Exclusive	splice_jorge_144	0.57	1.72	2.25	1.46	3.06
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	0.75	2.40	3.29	1.90	4.23
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	0.56	1.44	2.14	1.29	2.62
splice_jorge_144 Exclusive	Overlap	0.87	1.93	1.67	1.58	2.47
ad_gs_25 Exclusive	Overlap	1.00	2.81	2.22	2.94	2.91
Overlap	Exclusives	0.59	3.07	3.42	1.56	3.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	0.00	3.05	3.25	2.28	0.40
ad_gs_25 Exclusive	splice_jorge_144	0.01	2.57	4.42	2.11	3.09
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	0.00	2.33	1.84	1.60	4.13
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	0.01	1.33	3.24	0.77	2.41
splice_jorge_144 Exclusive	Overlap	0.00	0.92	1.42	1.69	5.56
ad_gs_25 Exclusive	Overlap	0.03	133.21	55.70	153.56	12.37
Overlap	Exclusives	0.03	25.04	30.19	11.68	20.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_jorge_144 Exclusive	141	141	
ad_gs_25 Exclusive	22	22	
Overlap	3	3