Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
shima_spliceai_141 Exclusive	ad_gs_25	5.53e-01	8.80e-01	6.94e-01	1.42e-01
ad_gs_25 Exclusive	shima_spliceai_141	6.90e-01	5.06e-02	1.69e-02	1.26e-02
shima_spliceai_141 Exclusive	ad_gs_25 Exclusive	8.17e-01	7.47e-01	6.87e-01	1.95e-01
ad_gs_25 Exclusive	shima_spliceai_141 Exclusive	5.59e-01	8.95e-02	9.13e-03	3.25e-02
shima_spliceai_141 Exclusive	Overlap	3.74e-01	6.40e-01	3.34e-01	1.07e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	4.77e-02	1.95e-02	1.79e-14	3.28e-03



Evaluating how well shima_spliceai_141 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_141 Exclusive	ad_gs_25	0.62	0.44	-0.42	-0.02	1.92
ad_gs_25 Exclusive	shima_spliceai_141	0.56	0.86	2.15	1.28	2.29
shima_spliceai_141 Exclusive	ad_gs_25 Exclusive	0.61	0.09	-0.36	-0.09	1.75
ad_gs_25 Exclusive	shima_spliceai_141 Exclusive	0.55	0.60	1.85	0.98	1.87
shima_spliceai_141 Exclusive	Overlap	0.75	0.68	-0.32	0.38	1.54
ad_gs_25 Exclusive	Overlap	1.00	2.94	2.23	2.69	3.07
Overlap	Exclusives	0.59	2.22	3.29	1.44	4.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_141 Exclusive	ad_gs_25	0.00	0.16	-0.79	-0.35	0.59
ad_gs_25 Exclusive	shima_spliceai_141	0.01	0.44	2.24	0.92	2.17
shima_spliceai_141 Exclusive	ad_gs_25 Exclusive	0.00	-0.19	-0.88	-0.19	0.06
ad_gs_25 Exclusive	shima_spliceai_141 Exclusive	0.01	-0.46	0.56	-0.11	0.69
shima_spliceai_141 Exclusive	Overlap	0.00	0.23	-0.06	0.30	2.30
ad_gs_25 Exclusive	Overlap	0.03	90.71	72.48	90.07	5.65
Overlap	Exclusives	0.02	18.71	20.52	10.76	12.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
shima_spliceai_141 Exclusive	138	138	
ad_gs_25 Exclusive	22	22	
Overlap	3	3