Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_intersection_130 Exclusive	ad_gs_25	4.06e-01	9.42e-01	5.17e-01	5.38e-02
ad_gs_25 Exclusive	splice_intersection_130	7.37e-01	3.35e-02	1.35e-02	1.90e-02
splice_intersection_130 Exclusive	ad_gs_25 Exclusive	2.68e-01	9.14e-01	6.69e-01	5.08e-02
ad_gs_25 Exclusive	splice_intersection_130 Exclusive	7.14e-01	5.61e-02	1.82e-02	4.55e-02
splice_intersection_130 Exclusive	Overlap	2.41e-01	7.04e-01	2.41e-01	1.36e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	2.33e-02	7.19e-03	4.63e-17	8.79e-04



Evaluating how well splice_intersection_130 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_intersection_130 Exclusive	ad_gs_25	0.64	0.79	0.12	0.25	2.13
ad_gs_25 Exclusive	splice_intersection_130	0.56	1.39	2.26	1.60	2.31
splice_intersection_130 Exclusive	ad_gs_25 Exclusive	0.62	0.77	0.35	-0.04	2.01
ad_gs_25 Exclusive	splice_intersection_130 Exclusive	0.55	0.76	2.13	1.00	1.82
splice_intersection_130 Exclusive	Overlap	0.76	1.11	0.07	0.43	1.85
ad_gs_25 Exclusive	Overlap	1.00	2.87	2.00	2.79	3.16
Overlap	Exclusives	0.59	2.56	3.63	1.76	3.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_intersection_130 Exclusive	ad_gs_25	0.00	0.29	-0.56	-0.10	1.03
ad_gs_25 Exclusive	splice_intersection_130	0.01	0.92	3.15	2.18	2.74
splice_intersection_130 Exclusive	ad_gs_25 Exclusive	0.00	0.24	-0.31	-0.27	0.40
ad_gs_25 Exclusive	splice_intersection_130 Exclusive	0.01	-0.20	1.26	-0.02	0.69
splice_intersection_130 Exclusive	Overlap	0.00	0.98	-0.06	0.55	1.54
ad_gs_25 Exclusive	Overlap	0.03	80.63	51.67	141.18	31.94
Overlap	Exclusives	0.02	19.98	26.89	15.87	13.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_intersection_130 Exclusive	127	127	
ad_gs_25 Exclusive	22	22	
Overlap	3	3