Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
diff_15	ad_gs_25	2.21e-04	1.25e-05	1.99e-06	2.87e-06
ad_gs_25	diff_15	8.83e-01	8.99e-01	7.59e-01	2.02e-01



Evaluating how well diff_15 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
diff_15	ad_gs_25	0.81	2.38	4.55	2.45	6.24
ad_gs_25	diff_15	0.61	0.70	0.46	0.57	1.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
diff_15	ad_gs_25	0.02	21.64	44.14	16.66	14.29
ad_gs_25	diff_15	0.01	18.61	15.38	27.37	18.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
diff_15	15	15	
ad_gs_25	25	25