Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
common_Splice_jorge_shima Exclusive	ad_gs_25	2.10e-01	9.19e-01	7.21e-01	6.53e-02
ad_gs_25 Exclusive	common_Splice_jorge_shima	7.06e-01	4.20e-02	1.43e-02	2.78e-02
common_Splice_jorge_shima Exclusive	ad_gs_25 Exclusive	4.31e-01	9.65e-01	3.20e-01	5.77e-02
ad_gs_25 Exclusive	common_Splice_jorge_shima Exclusive	7.08e-01	5.85e-02	2.64e-02	3.63e-02
common_Splice_jorge_shima Exclusive	Overlap	2.68e-01	7.04e-01	3.19e-01	1.27e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.14e-02	6.26e-03	4.05e-17	9.37e-04



Evaluating how well common_Splice_jorge_shima genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
common_Splice_jorge_shima Exclusive	ad_gs_25	0.64	1.18	0.16	0.07	2.13
ad_gs_25 Exclusive	common_Splice_jorge_shima	0.56	1.10	2.01	1.42	2.42
common_Splice_jorge_shima Exclusive	ad_gs_25 Exclusive	0.62	0.60	0.22	0.25	2.01
ad_gs_25 Exclusive	common_Splice_jorge_shima Exclusive	0.55	1.03	1.85	0.95	1.98
common_Splice_jorge_shima Exclusive	Overlap	0.76	0.88	0.05	0.47	1.76
ad_gs_25 Exclusive	Overlap	1.00	3.08	2.26	2.81	2.99
Overlap	Exclusives	0.59	2.18	3.83	1.84	4.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
common_Splice_jorge_shima Exclusive	ad_gs_25	0.00	0.95	-0.64	-0.27	0.72
ad_gs_25 Exclusive	common_Splice_jorge_shima	0.01	1.42	2.59	1.08	2.45
common_Splice_jorge_shima Exclusive	ad_gs_25 Exclusive	0.00	0.21	-0.50	-0.20	0.04
ad_gs_25 Exclusive	common_Splice_jorge_shima Exclusive	0.01	-0.15	1.06	0.06	0.62
common_Splice_jorge_shima Exclusive	Overlap	0.00	0.93	-0.10	0.38	-0.03
ad_gs_25 Exclusive	Overlap	0.03	97.89	54.46	161.04	122.88
Overlap	Exclusives	0.02	20.47	28.83	13.16	17.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
common_Splice_jorge_shima Exclusive	127	127	
ad_gs_25 Exclusive	22	22	
Overlap	3	3