Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	1.89e-03	1.17e-02	2.69e-03	2.33e-05
ad_gs_25 Exclusive	splice_jorge_144	9.35e-01	5.04e-02	4.62e-03	2.64e-03
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	1.20e-02	1.83e-02	3.75e-03	6.26e-04
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	8.18e-01	4.79e-02	1.56e-02	3.43e-03
splice_jorge_144 Exclusive	Overlap	3.57e-01	6.49e-01	1.81e-01	5.47e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	2.02e-02	7.12e-03	9.74e-17	2.23e-03



Evaluating how well splice_jorge_144 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	0.76	2.46	3.53	2.22	4.54
ad_gs_25 Exclusive	splice_jorge_144	0.57	1.42	2.25	1.72	3.07
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	0.75	1.94	2.97	1.98	3.72
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	0.56	1.21	2.53	1.59	2.73
splice_jorge_144 Exclusive	Overlap	0.87	1.90	1.48	1.65	2.23
ad_gs_25 Exclusive	Overlap	1.00	2.87	1.88	2.96	3.20
Overlap	Exclusives	0.59	3.04	3.31	1.66	4.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
splice_jorge_144 Exclusive	ad_gs_25	0.00	2.87	2.32	1.81	2.54
ad_gs_25 Exclusive	splice_jorge_144	0.01	3.00	4.34	3.87	2.60
splice_jorge_144 Exclusive	ad_gs_25 Exclusive	0.00	2.19	2.71	1.39	3.10
ad_gs_25 Exclusive	splice_jorge_144 Exclusive	0.01	1.50	3.47	0.98	2.57
splice_jorge_144 Exclusive	Overlap	0.00	0.62	1.35	0.65	0.92
ad_gs_25 Exclusive	Overlap	0.03	85.88	48.95	181.15	85.07
Overlap	Exclusives	0.03	26.56	30.04	15.14	21.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
splice_jorge_144 Exclusive	141	141	
ad_gs_25 Exclusive	22	22	
Overlap	3	3