Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25	2.84e-02	1.44e-01	2.37e-02	3.11e-04
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8	5.77e-01	4.31e-02	5.99e-03	2.87e-03
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25 Exclusive	3.45e-02	1.45e-01	1.07e-02	1.69e-03
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8 Exclusive	3.80e-01	5.61e-02	2.71e-03	5.66e-03
shima_spliceai_167_z_2_8 Exclusive	Overlap	6.12e-01	6.58e-01	3.74e-01	1.32e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	5.77e-02	3.24e-02	1.33e-16	7.74e-03



Evaluating how well shima_spliceai_167_z_2_8 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25	0.74	1.73	2.81	1.72	3.75
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8	0.56	1.18	2.24	1.22	2.85
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25 Exclusive	0.72	1.83	2.42	1.89	3.62
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8 Exclusive	0.55	0.74	2.17	0.92	1.97
shima_spliceai_167_z_2_8 Exclusive	Overlap	0.83	1.59	0.68	1.12	2.00
ad_gs_25 Exclusive	Overlap	1.00	3.04	2.15	2.80	3.06
Overlap	Exclusives	0.58	2.27	2.62	1.36	3.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25	0.00	1.21	1.63	1.14	2.42
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8	0.01	1.44	3.31	1.61	2.99
shima_spliceai_167_z_2_8 Exclusive	ad_gs_25 Exclusive	0.00	1.40	1.33	0.97	0.89
ad_gs_25 Exclusive	shima_spliceai_167_z_2_8 Exclusive	0.01	0.66	1.76	0.50	1.32
shima_spliceai_167_z_2_8 Exclusive	Overlap	0.00	-0.07	0.17	0.14	0.31
ad_gs_25 Exclusive	Overlap	0.03	117.18	71.62	110.27	27.49
Overlap	Exclusives	0.03	22.32	20.36	16.44	22.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
shima_spliceai_167_z_2_8 Exclusive	165	165	
ad_gs_25 Exclusive	22	22	
Overlap	3	3