Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
shima_spliceai_z_2_8_ Exclusive	TIER1_GS	4.12e-02	1.19e-01	4.30e-03	3.69e-04
TIER1_GS Exclusive	shima_spliceai_z_2_8_	5.89e-01	1.92e-01	3.60e-01	2.52e-02
shima_spliceai_z_2_8_ Exclusive	TIER1_GS Exclusive	8.23e-03	1.03e-01	4.25e-03	1.40e-03
TIER1_GS Exclusive	shima_spliceai_z_2_8_ Exclusive	3.48e-01	2.48e-01	4.94e-01	4.54e-02
shima_spliceai_z_2_8_ Exclusive	Overlap	6.12e-01	6.85e-01	3.57e-01	1.11e-01
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.51e-02	5.59e-03	1.61e-17	2.02e-03



Evaluating how well shima_spliceai_z_2_8_ genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_z_2_8_ Exclusive	TIER1_GS	0.70	1.51	2.75	1.56	3.96
TIER1_GS Exclusive	shima_spliceai_z_2_8_	0.55	0.94	1.55	1.14	2.35
shima_spliceai_z_2_8_ Exclusive	TIER1_GS Exclusive	0.68	1.59	2.20	1.25	3.05
TIER1_GS Exclusive	shima_spliceai_z_2_8_ Exclusive	0.54	0.36	1.52	0.63	1.88
shima_spliceai_z_2_8_ Exclusive	Overlap	0.83	1.33	0.86	1.21	1.86
TIER1_GS Exclusive	Overlap	1.00	3.15	2.65	2.79	2.98
Overlap	Exclusives	0.59	3.72	3.83	1.83	4.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_z_2_8_ Exclusive	TIER1_GS	0.00	1.45	1.95	1.18	1.17
TIER1_GS Exclusive	shima_spliceai_z_2_8_	0.01	3.03	3.47	3.40	4.64
shima_spliceai_z_2_8_ Exclusive	TIER1_GS Exclusive	0.00	0.90	1.41	1.10	1.80
TIER1_GS Exclusive	shima_spliceai_z_2_8_ Exclusive	0.01	0.42	1.48	0.43	1.36
shima_spliceai_z_2_8_ Exclusive	Overlap	0.00	-0.08	0.24	0.33	0.84
TIER1_GS Exclusive	Overlap	0.03	96.06	112.57	190.39	42.55
Overlap	Exclusives	0.03	30.30	32.60	17.89	20.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
shima_spliceai_z_2_8_ Exclusive	165	165	
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3