Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25	2.08e-03	8.82e-03	5.41e-04	1.33e-04
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141	8.85e-01	2.62e-02	2.11e-03	2.45e-03
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25 Exclusive	1.27e-03	1.62e-02	9.43e-04	4.58e-04
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141 Exclusive	5.89e-01	3.58e-02	6.08e-03	4.35e-03
shima_spliceai_2_9_checkdiff_146_141 Exclusive	Overlap	3.19e-01	7.58e-01	2.35e-01	4.62e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	2.80e-02	1.12e-02	2.42e-17	1.02e-03



Evaluating how well shima_spliceai_2_9_checkdiff_146_141 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25	0.76	2.43	3.29	2.18	4.82
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141	0.57	1.38	2.36	1.61	3.12
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25 Exclusive	0.75	2.38	2.56	1.82	4.34
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141 Exclusive	0.56	1.11	2.22	1.64	2.50
shima_spliceai_2_9_checkdiff_146_141 Exclusive	Overlap	0.87	1.87	1.20	1.47	2.56
ad_gs_25 Exclusive	Overlap	1.00	2.93	2.19	2.86	2.85
Overlap	Exclusives	0.59	2.57	3.25	2.08	4.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25	0.00	3.14	1.61	1.69	4.73
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141	0.01	2.95	4.81	3.38	3.25
shima_spliceai_2_9_checkdiff_146_141 Exclusive	ad_gs_25 Exclusive	0.00	3.30	1.08	1.62	2.97
ad_gs_25 Exclusive	shima_spliceai_2_9_checkdiff_146_141 Exclusive	0.01	0.77	2.78	1.19	2.41
shima_spliceai_2_9_checkdiff_146_141 Exclusive	Overlap	0.00	1.65	1.12	0.90	0.39
ad_gs_25 Exclusive	Overlap	0.03	82.12	57.33	111.46	21.57
Overlap	Exclusives	0.03	28.35	25.68	14.93	21.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
shima_spliceai_2_9_checkdiff_146_141 Exclusive	143	143	
ad_gs_25 Exclusive	22	22	
Overlap	3	3